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This is an archived project. Repository and other project resources are read-only.
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center-for-computational-genomics-and-data-science
public
QuaC
Commits
729c88d7
Commit
729c88d7
authored
4 years ago
by
Manavalan Gajapathy
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refactors ped creator to include sex
parent
282365d1
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src/create_dummy_ped.py
+64
-11
64 additions, 11 deletions
src/create_dummy_ped.py
with
64 additions
and
11 deletions
src/create_dummy_ped.py
+
64
−
11
View file @
729c88d7
"""
Create dummy ped file by project
Usage:
ml reset
ml Anaconda3
conda activate quac_common
python src/create_dummy_ped.py
"""
from
pathlib
import
Path
import
pandas
as
pd
def
main
(
project_
name
,
outpath
):
def
read_
project_
tracker
(
project_tracker_f
):
project_path
=
Path
(
"
/data/project/worthey_lab/projects
"
)
/
project_name
/
"
analysis
"
df
=
pd
.
read_excel
(
project_tracker_f
,
usecols
=
[
"
CGDS ID
"
,
"
Sex
"
])
df
[
"
sex_ped
"
]
=
df
[
"
Sex
"
].
str
.
lower
().
map
({
"
m
"
:
"
1
"
,
"
f
"
:
"
2
"
})
df
[
"
sex_ped
"
]
=
df
[
"
sex_ped
"
].
fillna
(
"
-9
"
)
# unknown sex
sample_sex_dict
=
df
.
set_index
(
"
CGDS ID
"
)[
"
sex_ped
"
].
to_dict
()
return
sample_sex_dict
def
nbbbb
():
project_path
=
Path
(
"
/data/project/worthey_lab/projects
"
)
/
project_name
/
"
analysis
"
samples
=
(
f
.
name
for
f
in
project_path
.
iterdir
()
if
f
.
is_dir
()
and
f
.
name
.
startswith
((
"
LW
"
,
"
UDN
"
))
)
...
...
@@ -24,14 +42,49 @@ def main(project_name, outpath):
return
None
def
main
(
outpath
):
project_dict
=
{
"
CF_CFF_PFarrell
"
:
{
"
tracking_sheet
"
:
"
data/external/project_tracker/PROJECT TRACKING -CF.xlsx
"
,
"
affected
"
:
"
all
"
,
},
# "CF_TLOAF_PFarrell",
# "EDS3_unkn_DGreenspan",
# "MuscDyst_SU_MAlexander",
# "UDN_Phase1_EAWorthey",
}
for
project_name
in
project_dict
:
# get sample's sex info from project tracking sheet
sample_sex_dict
=
read_project_tracker
(
project_dict
[
project_name
][
"
tracking_sheet
"
])
# get samples from cheaha for the project
project_path
=
Path
(
"
/data/project/worthey_lab/projects
"
)
/
project_name
/
"
analysis
"
samples
=
(
f
.
name
for
f
in
project_path
.
iterdir
()
if
f
.
is_dir
()
and
f
.
name
.
startswith
((
"
LW
"
,
"
UDN
"
))
)
header
=
[
"
#family_id
"
,
"
sample_id
"
,
"
paternal_id
"
,
"
maternal_id
"
,
"
sex
"
,
"
phenotype
"
]
with
open
(
Path
(
outpath
)
/
f
"
{
project_name
}
.ped
"
,
"
w
"
)
as
out_handle
:
out_handle
.
write
(
"
\t
"
.
join
(
header
)
+
"
\n
"
)
for
sample
in
sorted
(
samples
):
data
=
[
"
unknown
"
,
sample
,
"
-9
"
,
# father
"
-9
"
,
# mother
sample_sex_dict
[
sample
],
# sample sex
"
1
"
if
project_dict
[
project_name
][
"
affected
"
]
==
"
all
"
else
"
-9
"
,
# affected
]
out_handle
.
write
(
"
\t
"
.
join
(
data
)
+
"
\n
"
)
return
None
if
__name__
==
"
__main__
"
:
OUT_PATH
=
"
data/raw/ped
"
# not so raw, is it?
# PROJECT_NAME = "MuscDyst_SU_MAlexander"
for
PROJECT_NAME
in
[
"
CF_TLOAF_PFarrell
"
,
"
CF_CFF_PFarrell
"
,
"
EDS3_unkn_DGreenspan
"
,
"
MuscDyst_SU_MAlexander
"
,
"
UDN_Phase1_EAWorthey
"
,
]:
main
(
PROJECT_NAME
,
OUT_PATH
)
main
(
OUT_PATH
)
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